© N. Budisa

The group works on "Protein Engineering" based on the in vivo incorporation of non-canonical amino acids into proteins. Our work includes organic synthesis of amino acids, studies on model peptides as well as the expression of target proteins in different host organisms. Our objective is to manipulate the protein translation machinery and, thus, the genetic code. This results in new possibilities to engineer and control cellular processes in a chemical way. Our long-term goal is the generation of synthetic cellular systems.