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Fluoroprolines as tools for protein design and engineering
Citation key 019.2001.renner
Author Renner, C. and Alefelder, S. and Bae, J. H. and Budisa, N. and Huber, R. and Moroder, L.
Pages 923-925
Year 2001
DOI 10.1002/1521-3773(20010302)40:5<923::AID-ANIE923>3.0.CO;2-#
Journal Angew. Chem. Int. Ed.
Volume 40
Number 5
Abstract The preference of the peptidyl−fluoroproline amide bond for the cis or trans conformation in the model compounds N-acetyl-4-fluoroproline methyl esters (see scheme) fully correlates with the thermostability of the related mutants of the model protein barstar. Thus, the (4S)-L-FPro mutants show a higher and the(4R)-L-FPro mutants a lower thermal stability than barstar.
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