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Global replacement of tryptophan with amino-tryptophans generates non-invasive protein-based optical pH sensors
Citation key 021.2002.budisa
Author Budisa, N. and Rubini, M. and Bae, J. H. and Weyher, E. and Wenger, W. and Golbik, R. and Huber, R. and Moroder, L.
Pages 4066-4069
Year 2002
DOI 10.1002/1521-3773(20021104)41:21<4066::AID-ANIE4066>3.0.CO;2-6
Journal Angew. Chem. Int. Ed.
Volume 41
Number 21
Abstract Functional protein design: Replacement of the tryptophan indole moiety in proteins with aminoindoles converts pH-insensitive into pH-sensitive fluorescent proteins (see picture). Such global substitution of residues in target proteins by noncanonical amino acids with defined spectral properties offers a unique approach for the design of protein-based molecular sensors.
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