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Publications 2005 - 2009

Fine tuning the N-terminal residue excision by methionine analogs
Citation key 057.2009.wiltschi
Author Wiltschi, B. and Merkel, L. and Budisa, N.
Pages 217-220
Year 2009
DOI 10.1002/cbic.200800605
Journal ChemBioChem
Volume 10
Number 2
Abstract The amino acid composition of the N terminus of a protein determines whether the first methionine residue is excised or not. Its replacement by a chemically distinct noncanonical analogue by an expanded genetic code affects the overall efficiency of this process. Recent advances have provided novel insight into the N-terminal residue excision rules; this certainly will enrich the repertoire of chemical protein engineering.
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