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Genetically encoded photocrosslinkers as molecular probes to study G-protein-coupled receptors (GPCRs)
Citation key 076.2011.beck
Author Beck-Sickinger, A. G. and Budisa, N.
Pages 310-312
Year 2011
DOI 10.1002/anie.201107211
Journal Angew. Chem. Int. Ed. Engl.
Volume 51
Number 2
Abstract The genetic code was expanded with orthogonal pairs to introduce photoactivatable amino acids into G-protein-coupled receptors (GPCRs) in a noninvasive manner. In this way the receptor surface could be mapped by searching for specific ligand interaction sites and the complex dynamics could be studied. This method is also useful for probing the structure of GPCR complexes in living cells.
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