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Publications 2010 - 2012

Bioconjugation of L-3,4-Dihydroxyphenylalanine Containing Protein with a Polysaccharide
Citation key 083.2011.ayyadurai
Author Ayyadurai, N. and Prabhu, N.S. and Deepankumar, K. and Jang, Y.J. and Chitrapriya, N. and Song, E. and Lee, N. and Kim, S.K. and Kim, B.G. and Soundrarajan, N. and Lee, S. and Cha, H.J. and Budisa, N. and Yun, H.
Pages 551-555
Year 2011
DOI 10.1021/bc2000066
Journal Bioconjugate.Chem.
Volume 22
Number 4
Abstract We describe the simple bioconjugation strategy in combination of periodate chemistry and unnatural amino acid incorporation. The residue specific incorporation of 3,4-dihydroxy-l-phenylalanine can alter the properties of protein to conjugate into the polymers. The homogeneously modified protein will yield quinone residues that are covalently conjugated to nucleophilic groups of the amino polysaccharide. This novel approach holds great promise for widespread use to prepare protein conjugates and synthetic biology applications.
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