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Publications 2010 - 2012

Site-selective modification of proteins for the synthesis of structurally defined multivalent scaffolds
Citation key 088.2012.artner
Author Artner, L. A. and Merkel, L. and Bohlke, N. and Beceren-Braun, F. and Weise, C. and Dernedde, J. and Budisa, N. and Hackenberger, C. P. R.
Pages 522 – 524
Year 2012
DOI 10.1039/C1CC16039G
Journal Chem. Commun.
Volume 48
Abstract A combination of classical site-directed mutagenesis, genetic code engineering and bioorthogonal reactions delivered a chemically modified barstar protein with one or four carbohydrates installed at specific residues. These protein conjugates were employed in multivalent binding studies, which support the use of proteins as structurally defined scaffolds for the presentation of multivalent ligands.
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