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On the Road towards Chemically Modified Organisms Endowed with a Genetic Firewall
Citation key 084.2011.acevedo
Author Acevedo-Rocha, C. G. and Budisa, N.
Pages 6960–6962
Year 2011
DOI 10.1002/anie.201103010
Journal Angew. Chem. Int. Ed. Engl.
Volume 50
Number 31
Abstract An automated system for the continuous cultivation of cells in suspension has been used to globally change the composition of the DNA genome of E. coli. Thymine was replaced almost completely by 5-chlorouracil through artificial evolution of cells, during which the bacterial genome accumulated hundreds of mutations under permanent conditions of proliferation and selection. The resulting 5-chlorouracil-adapted descendants had the ability to grow on 5-chlorouracil.
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