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Publications 2013 - 2015

Dendronylation: Residue-specific chemoselective attachment of oligoglycerol dendrimers on proteins with noncanonical amino acids
Citation key 134.2015.ma
Author Ma, Y. and Thota, B. N. S. and Haag, R. and Budisa, N.
Pages 5247-5249
Year 2015
DOI 10.1016/j.bmcl.2015.09.055
Journal Bioorg. Med. Chem. Lett.
Volume 25
Number 22
Abstract Polyglycerol dendrimers as an important class of polymeric materials especially attractive for covalent attachment to therapeutic proteins as a useful alternative to traditional PEGylation procedures. Herein, we combine in vivo noncanonical amino acid (ncAA) incorporation and chemoselective conjugation in vitro to produce novel hybrid protein–dendrimer conjugates with the defined architectures. We incorporated Azidohomoalanine (Aha) as methionine substitute in vivo into various protein scaffolds to allow non-invasive dendrimer conjugations (dendronylation). Our approach makes recombinant proteins accessible for the design of multivalent dendrimer conjugates since it enables the preparation of many sequences with various positions for regioselective dendronylation.
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