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Publications 2013 - 2015

Non-canonical amino acids as a useful synthetic biological tool for lipase-catalysed reactions in hostile environments
Citation key 104.2013.acevedo
Author Acevedo-Rocha, C.G. and Hoesl, M.G and Nehring, S. and Royter, M. and Wolschner, C. and Wiltschi, B. and Antranikian, G. and Budisa, N.
Pages 1198-1201
Year 2013
DOI 10.1039/C3CY20712A
Journal Catal. Sci. Technol.
Volume 3
Number 5
Abstract The incorporation of several non-canonical amino acids into the Thermoanaerobacter thermohydrosulfuricus lipase confers not only activity enhancement upon treatment with organic solvents (by up to 450%) and surfactants (resp. 1630%), but also protective effects against protein reducing (resp. 140%), alkylating (resp. 160%), and denaturing (resp.190%) agents as well as inhibitors (resp. 40%). This approach offers novel chemically diversified biocatalysts for hostile environments.
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