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TU Berlin

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Publikationen 2000 - 2004

Synthesis of b-(1-Azulenyl)-L-Alanine as a potential blue-coloures fluorescent tryptophan analogue and its use in peptide synthesis
Zitatschlüssel 014.2000.loid
Autor Loid, G. and Musiol, H.-J. and Budisa, N. and Huber, R. and Poirot, S. and Fourmy, D. and Moroder, L.
Seiten 139-144
Jahr 2000
Journal J. Peptide Sci.
Jahrgang 6
Nummer 3
Zusammenfassung Acetyl-beta-(1-azulenyl)-D,L-alanine has been synthesized in high overall yield by the malonic ester condensation procedure, and the racemate has been enzymatically resolved with acylase I from Aspergillus melleus. The enantiomerically pure L-amino acid is of interest as a blue-colored fluorescent tryptophan analog. The bioactivity data of a heptagastrin analog containing it suggests that the planar aromatic azulene moiety may indeed mimic the tryptophan side chain to some extent, and the spectral properties of the azulene moiety makes beta-(1-azulenyl)-L-alanine of potential value as a UV and fluorescence probe in synthetic peptides, and possibly even in proteins if bioincorporation succeeds with chemically misacylated tRNAs.
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